Alan Menter, MD Dermatologist Chief, Division of Dermatology Baylor Scott & White Clinical Professor of Periodontics Baylor College of Dentistry Clinical Professor of Dermatology University of Texas Southwestern Medical Center Co-Chair, Psoriasis Guidelines Committee for the American Academy of Dermatology Dallas , TX

Statement of Need

Recent years have seen an increase in the number of therapeutic monoclonal antibodies (mAbs) that are available to treat a variety of conditions caused by immune-mediated chronic inflammation such as psoriasis. Health care professionals are often presented with complex and conflicting information surrounding concepts of mAb production and immunogenicity; therefore, there is a significant need for education in this area, especially as distinguishing the relative clinical efficacy and safety profiles of one mAb relative to another can be difficult and complex due to different clinical designs and a lack of head-to-head comparator studies.

In this CME Outfitters interactive infographic expert faculty evaluates the development of mAbs and anti drug antibodies (ADAs) by analyzing the history of and present-day inconsistencies in the nomenclature and their effects on therapeutic response.

Learning Objectives

At the end of this CE activity, participants should be able to:

• Evaluate processes utilized to develop monoclonal antibodies (mAbs), including principles of design and modification as well as technologies used in production.
• Analyze the history of and present-day inconsistencies in the nomenclature of mAbs in order to increase understanding of the clinical characteristics of specific molecules.
• Integrate insights into the development of anti drug antibodies (ADAs), their effects on therapeutic response, and advances in laboratory detection of them into clinical practice.

Financial Support

This activity is supported by an educational grant from Lilly. For further information concerning Lilly grant funding visit www.lillygrantoffice.com

Target Audience

Dermatologists, physician assistants, and nurse practitioners.

Credit Information

CME Credit (Physicians):
CME Outfitters, LLC, is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

CME Outfitters, LLC, designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit(s)^TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

ABIM/MOC Credit:
Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.0 MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

Learning Formats
Enduring activity

MIPS Improvement Activity: This activity counts towards MIPS Improvement Activity requirements under the Medicare Access and CHIP Reauthorization Act of 2015 (MACRA). Clinicians should submit their improvement activities by attestation via the CMS Quality Payment Program website.

AANP Credit (American Association of Nurse Practitioners):

This activity is approved for 1.0 contact hour of continuing education (which includes 1.0 hour of pharmacology) by the American Association of Nurse Practitioners. Activity ID 19063761. This activity was planned in accordance with AANP Accreditation Standards and Policies.

AAPA Credit (American Academy of PA's):

This activity has been reviewed by the AAPA Review Panel and is compliant with AAPA CME Criteria. This activity is designated for 1.00 AAPA Category 1 CME credits. Approval is valid for one year from 07/10/2019. PAs should only claim credit commensurate with the extent of their participation.

Post-tests, credit request forms, and activity evaluations must be completed online (requires free account activation), and participants can print their certificate or statement of credit immediately (75% pass rate required). This website supports all browsers except Internet Explorer for Mac. For complete technical requirements and privacy policy, visit https://www.cmeoutfitters.com/privacy-and-confidentiality-policy

Disclosure Declaration

It is the policy of CME Outfitters, LLC, to ensure independence, balance, objectivity, and scientific rigor and integrity in all of their CE activities. Faculty must disclose to the participants any relationships with commercial companies whose products or devices may be mentioned in faculty presentations, or with the commercial supporter of this CE activity. CME Outfitters, LLC, has evaluated, identified, and attempted to resolve any potential conflicts of interest through a rigorous content validation procedure, use of evidence-based data/research, and a multidisciplinary peer review process. The following information is for participant information only. It is not assumed that these relationships will have a negative impact on the presentations.

Dr. Menter has no disclosures to report.

Tony Graham, MD (peer reviewer) has no disclosures to report.

Mae Ochoa, RPh (peer reviewer) has no disclosures to report.

Susan Perry (planning committee) has no disclosures to report.

Jan Perez (planning committee) has no disclosures to report.

Sharon Tordoff (planning committee) has no disclosures to report.

Disclosures were obtained from the CME Outfitters, LLC staff: No disclosures to report.

Faculty of this CE activity may include discussions of products or devices that are not currently labeled for use by the FDA. The faculty has been informed of their responsibility to disclose to the audience if they will be discussing off-label or investigational uses (any uses not approved by the FDA) of products or devices.

Questions about this activity? Call us at 877.CME.PROS(877.263.7767).

IN-002-111919-11